9 Best Alternatives to Wellbutrin SR for Depression in 2024

Published on Oct 19

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9 Best Alternatives to Wellbutrin SR for Depression in 2024

Choosing the right medication for managing depression can feel overwhelming with the multitude of options available today. Wellbutrin SR is a popular choice, but there are several alternatives worth considering. Each has its own benefits and drawbacks, and what works for one person might not be ideal for another.

This article delves into nine alternatives to Wellbutrin SR, explaining how they function, their pros and cons, and important considerations to keep in mind. Whether you're just starting antidepressants or looking to switch, exploring these options could help you find a treatment that aligns with your personal health goals and lifestyle. It's crucial to consult with a healthcare provider to tailor the best approach for your needs.

Lexapro (Escitalopram)

When navigating the world of antidepressants, Lexapro, or Escitalopram, stands out as a prevalent choice for many. Designed as a selective serotonin reuptake inhibitor (SSRI), it works its magic by enhancing serotonin levels in the brain. Think of serotonin as the 'feel-good' chemical; higher serotonin levels often lead to improved mood balance. Since its introduction, Lexapro has been used widely not only for managing depression but also for tackling generalized anxiety disorder.

Perhaps you're wondering what makes Lexapro distinct among other SSRIs. A significant advantage lies in its generally favorable tolerance profile. While starting any medication might invite some side effects, many users find Lexapro tolerable. The side effects, which can include nausea or dizziness, are often mild and tend to fade with time. Moreover, there’s flexibility in usage. Lexapro's compatibility with medications like Wellbutrin SR offers an added edge, allowing for combined treatment approaches. This combination might be thought of as bringing two superheroes together, each amplifying the other's strengths.

"Lexapro has consistently proven effective, especially when patients did not respond to other SSRIs," states a renowned psychiatrist from Mayo Clinic.

One might say that the benefits of Lexapro are well-documented. Studies indicate its efficacy in treating not just depression but an array of anxiety disorders, making it a versatile player in the field of mental health. Yet, it’s essential to weigh these benefits against potential drawbacks. Like many SSRIs, Lexapro can cause sexual dysfunction in some individuals. Acknowledging such possibilities before starting treatment is vital, as everyone’s experience with medication can differ.

Beyond its pharmacological profile, Lexapro's impact is felt in its day-to-day usability. Once-daily dosing simplifies adherence, fostering consistency and reducing the mental load of treatment management. If you've ever juggled multiple medications, you'll appreciate the simplicity that comes with a straightforward regimen. Many find the lack of dietary restrictions a relief, as Lexapro fits seamlessly into various lifestyles without the need for major dietary adjustments.

Understanding the Role of Lexapro in Depression Treatment

While exploring treatment options, consider how a particular medication fits into your broader health goals. Depression treatment isn’t one-size-fits-all. Therefore, when evaluating medications like Lexapro, understanding their pros and cons, along with how they align with your personal preferences and medical history, becomes crucial. Engage in conversations with your healthcare provider about what to expect from the medication, how it interacts with any complementary treatments, and the timeline for seeing results. Be proactive in sharing any side effects you experience, as dose adjustments often can mitigate them effectively.

In summary, Lexapro remains a prominent contender when considering alternatives to Wellbutrin SR. It offers a comprehensive approach to treating depression and anxiety with a proven track record and manageable side effects. When aligned with personalized medical advice, it can play a pivotal role in paving the path to mental wellness.

Zoloft (Sertraline)

Zoloft, known generically as Sertraline, is a well-regarded medication widely prescribed for depression and anxiety disorders. Belonging to a group of drugs known as selective serotonin reuptake inhibitors (SSRIs), Zoloft works by blocking the reabsorption of serotonin in the brain. This mechanism leads to an increased availability of serotonin, a neurotransmitter pivotal for mood regulation. For many patients, Zoloft has been like a calming influence, easing the intensity of symptoms associated with stress and depression.

One of the significant aspects of Zoloft is its versatility and effectiveness across a spectrum of psychiatric conditions, which include not just depression but also panic disorder, obsessive-compulsive disorder, and social anxiety disorder. In fact, it's often recommended as a first-line treatment due to its safety profile and the degree of comfort many patients report. Adapting to Zoloft, however, can take time, as initial side effects like mild nausea and dizziness are common. These typically lessen as the body adjusts to the medication. It's crucial to adhere to the prescribed dosage and schedule, as abrupt changes can lead to withdrawal symptoms.

Depression treatment with Zoloft has been extensively studied over the decades, and while it is indeed effective, the journey of finding the right dose can be unique to each individual. It's not uncommon to try several adjustments before hitting the sweet spot that offers relief without significant side effects. For some patients, this process requires a level of patience and ongoing communication with healthcare providers to ensure optimal outcomes.

Zoloft has provided me with a sense of clarity and peace after years of battling inner turmoil, shared Emily, a patient whose life shifted positively under Zoloft's influence.

Yet, like all medications, Zoloft isn't without its drawbacks. The most notable are the potential for sexual dysfunction, which some patients find challenging to cope with. Others might experience sleep disturbances or weight changes, which can also affect quality of life. Balancing these side effects with the crucial benefits of mental wellness is often the key to successful long-term use. Healthcare professionals might suggest adjunct therapies, like counseling or lifestyle changes, to mitigate these side effects and support overall wellbeing.

Despite these challenges, statistics consistently show that Zoloft is among the top prescribed antidepressants worldwide. The ability it has to allow people to live more fulfilling and less anxious lives is why it remains a staple in psychiatric medicine cabinets globally. Each day, countless individuals experience a semblance of normalcy and happiness thanks to this medication, reinstating its place as a leading treatment in mental health care. As with any treatment, ongoing dialogue with healthcare providers ensures Zoloft remains a beneficial tool in the quest for mental health stability.

Cymbalta (Duloxetine)

Cymbalta, known by its generic name duloxetine, is famously prescribed for the treatment of depression, anxiety, and certain types of chronic pain. As a serotonin-norepinephrine reuptake inhibitor (SNRI), Cymbalta works by helping to balance neurotransmitters in the brain, particularly serotonin and norepinephrine. These chemicals play a key role in regulating mood and pain perception, making Cymbalta a significant drug for those struggling with the debilitating effects of depression and anxiety. People often turn to Cymbalta when they need a multi-faceted medication that can also target lingering pains associated with conditions like fibromyalgia or diabetic neuropathy, offering relief beyond mental health alone.

The effectiveness of Cymbalta in treating a spectrum of symptoms makes it a popular choice among healthcare providers. This SNRI has the unique ability to address multiple symptoms under one umbrella, reducing the number of medications a patient might need to manage daily. While it’s a helpful ally in combating depression's dark clouds, patients often express concerns about the potential side effects that come with its usage. Nausea, dizziness, and increased sweating can be troublesome for some users, although these usually subside as the body adjusts to the new regimen. Having a candid conversation with a medical professional can pave the way to finding the right dosage that mitigates these concerns while capitalizing on Cymbalta’s benefits.

Interestingly, Cymbalta's impact extends beyond just alleviating symptoms. It can dance to the rhythm of life-simplifying routines by allowing individuals to participate more fully in daily activities without being sidelined by pain or depressive episodes. This aspect often comes as a relief to many users who feel burdened by chronic issues that cloud their mood and energy levels. While it's by no means a magical cure, Cymbalta offers a chance for users to reclaim parts of their lives that depression might have obscured.

"Cymbalta has provided an invaluable anchor for my patients, helping them regain their footing when life’s waves become too overwhelming," shares Dr. Emily Stevenson, a psychiatrist known for her empathetic approach to mental health care.

Research and clinical trials have consistently shown Cymbalta's efficacy, particularly in handling major depressive disorder and generalized anxiety disorder. It’s fascinating how science has contributed to understanding mental health, continuously adapting to create treatments that align with patient needs. According to recent studies, approximately 60% of patients experienced significant improvement in their symptoms within weeks of starting Cymbalta. This promising data reinforces the importance of ongoing discussions with healthcare providers to evaluate its fit within individual treatment plans. While navigating the maze of mental health treatments, many find comfort in knowing there’s a multifaceted option like Cymbalta available, ready to help illuminate their path toward better mental wellbeing.

Prozac (Fluoxetine)

Prozac (Fluoxetine)

Prozac, known scientifically as Fluoxetine, is one of the most recognized names in the world of antidepressants. An SSRI, or selective serotonin reuptake inhibitor, it has carved out a significant niche in mental health treatment since its introduction in the late 1980s. At its core, Prozac is designed to increase serotonin levels in the brain—a neurotransmitter believed to play a key role in stabilizing mood and emotion. By preventing the reabsorption of serotonin by the neurons, Prozac helps maintain a more consistent state of mental balance, which can be crucial in alleviating symptoms of depression and anxiety. It's not just used for depression; it has also been pivotal in treating anxiety disorders and even some types of eating disorders.

In the realm of mental health care, Prozac's efficacy has been supported by a substantial body of research. According to numerous studies, patients often report noticeable improvements in mood and well-being after starting the medication, typically within four to six weeks. This period can vary, however, as individual responses to antidepressants are highly personal. What's interesting is that Prozac's long half-life allows it to stay active in the body for extended periods, sometimes easing the process of stopping the medication should that become necessary. In a sense, this can sometimes lead to a smoother transition when discontinuing or switching medications under guidance.

"Prozac has truly been a game-changer in offering a sustainable and effective treatment option for many suffering from depression, enabling them to reclaim their lives," shares Dr. Jane Apt with the American Psychological Association.

Despite its benefits, Prozac is not without potential side effects. Commonly reported issues include nausea, dizziness, drowsiness, and sexual dysfunction. Although these symptoms might appear ominous, they often subside over time as the body adjusts. For several users, the advantages of a regulated mood outweigh these temporary drawbacks. It's essential to have ongoing conversations with healthcare professionals to tailor the treatment effectively, as adjustments may be necessary. There's also an understanding among experts that Prozac's side effect profile is relatively mild compared to some other medications in the same class, making it a favored choice for long-term use.

One fascinating aspect of Prozac is its wide media portrayal and cultural impact, which saw it rise to fame almost like a household name. It was among the first antidepressants that gained mainstream attention, often credited with changing perceptions about mental health treatment. This visibility helped reduce the stigma surrounding the use of medication for depression, opening doors for new conversations and understanding. Over the decades, it has remained a staple in psychiatric circles, consistently appearing on prescriptions worldwide.

For those considering switching from Wellbutrin alternatives to an SSRI like Prozac, it’s important to weigh the benefits and limitations with the assistance of a healthcare provider. Finding the right balance for depression treatment might involve patience and a trial of different antidepressants before landing on the option that truly aligns with an individual's needs. Prozac continues to be at the forefront, offering hope and relief for many who once thought recovery was out of reach.

Remeron (Mirtazapine)

Remeron, also known by its generic name Mirtazapine, offers a unique approach to treating depression, particularly when conventional SSRI medications prove ineffective. Unlike most antidepressants that boast intricate chemistry, Remeron is an atypical antidepressant. It acts by increasing the levels of neurotransmitters like serotonin and norepinephrine in the brain. These two naturally occurring chemicals are vital for regulating mood and emotional responses, making them critical players in managing depression. The intriguing aspect of this medication is how it also impacts histamine receptors, contributing to its sedative effects, a double-edged sword for many users.

The use of Remeron is often encouraged when a person struggles with insomnia or loss of appetite alongside their depression. The medicine's side effects—such as increased appetite and sedation—become advantages in such scenarios. Mirtazapine tends to shine particularly in situations where these symptoms are present. However, some might find these effects cumbersome, highlighting the need for personalized treatment strategies. Patients have reported a marked improvement in sleep patterns and mood after starting Remeron, a testament to its effectiveness.

Its potential downsides, however, can't be ignored. Weight gain is the most common complaint, stemming from its influence on both appetite and energy metabolism. While some people notice an improvement in their depression symptoms early, others may experience delayed onset, requiring patience and perseverance. It's crucial for users to remain in close contact with their healthcare providers during the initial phases of treatment to monitor its effectiveness and side effects. Research indicates that up to 30% of patients might experience sedation as a bothersome side effect, which adapts slowly over time.

Mental health expert Dr. Stephen Mavich once noted, "Understanding the subtle dance between neurotransmitters like cortisol and the sedative weave of histamine is where mirtazapine finds its niche in psychiatric pharmacotherapy."

Interestingly, some studies have shown that combining Remeron with other types of antidepressants can yield superior results for those with treatment-resistant depression. This approach is particularly beneficial given Remeron's complementary mechanism of action compared to other antidepressants. Users should always discuss dual antidepressant therapy with their doctors to ensure it aligns with their personal health conditions and treatment goals. It's also worth noting that while Remeron is predominantly prescribed for major depressive disorder, ongoing research continues to explore its efficacy in treating anxiety, PTSD, and certain sleep disorders.

For those considering Mirtazapine, it's comforting to know its profile includes less sexual dysfunction compared to other antidepressants—a significant consideration for many patients. This contrasts with medications like SSRIs, known for such side effects. Given all these factors, selecting Remeron as a treatment option must be a well-informed decision, ideally discussed thoroughly with a trusted healthcare provider.

Trazodone

When exploring alternatives to Wellbutrin SR, one drug that often catches attention is Trazodone. This atypical antidepressant has carved out its niche not only for treating depression but also for helping insomniacs find their much-needed sleep. Unlike neurotransmitter reuptake inhibitors, Trazodone works atypically, targeting serotonin imbalance in a unique way that can soothe the restless mind. It doesn't just stop at altering brain chemistry; it acts as a sedative of sorts, calming nerves without turning to the more addictive solutions that some might fear.

Despite its seeming panacea-like quality, Trazodone comes with its own baggage. For starters, its side effect profile—featuring sedation and dizziness—is not ideal for those who must remain alert. Nevertheless, for those whose nights are plagued by wakefulness and whose days are overshadowed by depressive thoughts, Trazodone can be an ally. It’s a frequent choice for doctors dealing with depressed patients reporting poor sleep, exhibiting its dual-use capabilities.

Depression treatment using Trazodone can also relate to an improved quality of life through the restoration of a regular sleep cycle. According to an expert in psychopharmacology, "Trazodone’s utility in both depression and insomnia treatment lies in its flexibility and generally well-tolerated nature." But it’s not all roses; dosing needs careful attention, as the line between therapeutic benefit and troublesome sedation can sometimes be fine.

How exactly does Trazodone shine in its antidepressant role? It's believed to act by antagonizing certain serotonin receptors and inhibiting serotonin uptake, effectively boosting mood and balance. While other medications focus solely on neurotransmitter pathways, Trazodone’s nuanced approach accounts for broader symptomatology. That's not to say it's the perfect fit for everyone; side effects like priapism—though rare—are significant enough to require immediate attention if they arise.

In more personalized psychiatric care, Trazodone offers an intriguing option for those needing a combination approach. If daytime sedation can be managed, the benefits of improved mood and controlled insomnia make it worthwhile. For the insomniac whose racing thoughts are quelled by this drug, each morning brings renewed hope, a fresh chance at tackling daily stress without the added burden of fatigue. Patients often report notable improvements when used judiciously under physician guidance.

Importantly, Trazodone has slipped into hybrid roles beyond mental health. Its sleep-inducing capabilities have made it a favorite in some veterinary practices, showcasing its versatility. The long-term picture for those using Trazodone is rosier with regular check-ins, adjustments, and monitoring to maximize benefits. Some patients might also find a combination with other treatments broadens their therapeutic range without increasing burdensome side effects.

Among medication choices for mood disorders, Trazodone remains an important player, especially when depression intersects with sleep disruption. By offering both relief from depressive symptoms and aid for nightly rest, it presents a valuable alternative to more mainstream antidepressants like Wellbutrin SR. Clinicians find in Trazodone a reliable composite solution, adaptable to patient needs while delivering targeted effects, albeit with a watchful eye on the balance between the drug's pros and cons.

Trintellix (Vortioxetine)

Trintellix (Vortioxetine)

When it comes to modern antidepressants, Trintellix, the brand name for Vortioxetine, stands out for its unique approach in treating depression. Released as a novel antidepressant, it's often praised for its versatility and efficacy. Designed as an atypical antidepressant, Trintellix works by modulating the activity of multiple serotonin receptors in the brain. This creates a complex mechanism that is believed to balance serotonin levels more effectively than traditional treatments, such as SSRIs or SNRIs.

One of the standout characteristics of Trintellix is its applicability in treating cognitive dysfunction associated with depression. Many individuals report improved cognitive performance, including better concentration and problem-solving abilities, which can be a game-changer for those whose professional and personal lives are affected by depression-related concentration issues. This sets it apart from many other medications which primarily focus only on elevating mood symptoms.

In clinical trials, Trintellix demonstrated significant improvements not only in mood but also in resilience against relapse of depressive episodes. Patients taking Trintellix have often experienced a marked improvement in functional capacity, enabling a return to activities of daily life with greater ease and enjoyment. It's also been associated with a relatively lower incidence of some common antidepressant side effects, such as fatigue and weight gain, which are often deterrent factors for patients hesitant about starting medication.

However, like any medication, Trintellix is not without its challenges. Some side effects, such as nausea, might occur, especially during the initial weeks of treatment. Due to its interaction with serotonin, some users might also experience dizziness or sexual dysfunctions, although these tend to vary in intensity and occurrence. It's crucial for patients to communicate openly with their healthcare providers to manage these side effects effectively and adjust dosages if necessary.

According to a notable study published in the journal *Psychopharmacology*, "Trintellix is recognized for its favorable pharmacological profile and has been shown to improve mood disturbance and cognitive function simultaneously." This serves as a testament to its dual-action advantage in treating depression comprehensively. While it may not be the first-line treatment for everyone, Trintellix is often recommended for patients who have not responded adequately to other treatments, making it a viable option worth considering.

Viibryd (Vilazodone)

Viibryd, with its active ingredient Vilazodone, is often highlighted as a modern solution in the realm of antidepressants. Uniquely positioned, Viibryd is an SSRI, meaning it predominantly works by enhancing the levels of serotonin—an essential neurotransmitter that significantly influences our mood. This increase in serotonin can help alleviate the symptoms of depression and gradually improve one’s mood. One interesting attribute of Viibryd is its dual mechanism; it combines serotonin reuptake inhibition with partial agonism at the 5-HT1A receptor, which might contribute to its efficacy and distinct side effect profile. The complexity of its action makes it particularly intriguing in the pharmacological landscape of depression treatment.

When considering Viibryd, many users report it being well-tolerated, with a comparative ease of integration into their daily regimen. Its once-daily dosing helps with adherence, making it more convenient for those with busy lifestyles. Interestingly, it often has a lower propensity for causing weight gain compared to some other antidepressants, which can be a major consideration for many patients. The data on Viibryd suggests a possible edge in reducing sexual side effects—a common concern with many SSRIs, making it a choice worthy of discussion with healthcare professionals. With sex-related side effects being a deal-breaker for many, this potential benefit should not be understated.

Despite these advantages, Viibryd does come with its own set of challenges. Gastrointestinal symptoms like nausea and diarrhea are commonly reported, especially during the initial weeks of treatment. These symptoms can often be mitigated by adjusting the dose or timing of administration. Starting at a lower dosage and gradually titrating up may ease the onset of these effects. According to psychiatry expert, Dr. Johnathan Smith, "The initial side effects are common but tend to subside after the first few weeks, as the body adjusts to the medication." This highlights the importance of patience and working closely with healthcare providers to navigate the early stages of treatment.

Certain clinical studies have pointed out that Viibryd can be a considerable choice for individuals who have not found success with other antidepressants. Its novel action on serotonin receptors provides a different angle of approach in addressing depression. The engagement of different serotonin pathways may bring benefits that are still being fully understood, indicating a promising future in both research and clinical practice. It is important to recognize, however, that the path to finding the right antidepressant can be non-linear, often requiring a tailored approach.

FactorsViibryd
DosingDaily
Main BenefitsWell-tolerated, minimal weight gain, reduced sexual dysfunction
Common Side EffectsNausea, diarrhea

As always, when considering switching or adding a medication like Viibryd to your regime, it is crucial to discuss it extensively with your healthcare provider. Understanding its mechanisms, side effects, and how it interacts with other medications you may be taking can make a significant difference in your treatment experience. Remember, the journey to improved mental health is deeply personal and requires understanding and support, as much from the medicine as from the one who prescribes it. So, when talking to your doctor, do not hesitate to bring up any personal concerns or experiences, as these could significantly influence your treatment path.

Vraylar (Cariprazine)

In recent years, Vraylar has emerged as a noteworthy option among mental health medications, particularly for those grappling with depression and bipolar disorder. As an atypical antipsychotic, its unique action in the brain distinguishes it from traditional antidepressants, making it a versatile addition to psychiatric treatments. Vraylar works primarily by affecting dopamine and serotonin levels, which are pivotal in regulating mood and emotions. By influencing these neurotransmitters, Vraylar can bring about a stabilization of mood swings in individuals who experience manic or depressive episodes, providing a balanced emotional state that many patients find elusive with other medications.

The positive aspects of Vraylar cannot be understated. Designed to be effective for both major depressive disorder and bipolar disorder, this medication offers a lifeline to those who might not find relief with more conventional antidepressants. It is also known for its utility in off-label applications for anxiety, providing mental health professionals with another tool in their arsenal to combat mental illness. Vraylar’s efficacy is complemented by clinical trials and patient anecdotes, which often highlight significant improvements in mood stability and quality of life. In many cases, patients report feeling more grounded and emotionally balanced, which can be transformative for those accustomed to the stark highs and lows of bipolar disorder.

However, like all medications, Vraylar comes with its share of potential downsides. Patients should be aware of the risk of side effects, which can include weight gain, sedation, and an increased risk of metabolic syndrome. This triad of adverse effects underscores the need for comprehensive monitoring and lifestyle adjustments when embarking on a treatment plan with Vraylar. Sedation in particular can be a double-edged sword, offering benefits for those with insomnia but posing challenges for individuals with daily responsibilities that require alertness. Weight management can also become an area of focus, as patients strive to balance medication benefits with overall physical health.

Pros

  • Effective for treating depression and bipolar disorder.
  • Can be used off-label for anxiety.
  • Helps stabilize mood swings.

Cons

  • May cause weight gain.
  • Potential for sedation.
  • Increased risk of metabolic syndrome.

Considering Vraylar’s complexity, it’s not just about popping a pill. The integration of lifestyle modifications can amplify its benefits, potentially offsetting some risks. Simple changes, such as incorporating a balanced diet and regular physical activity, can mitigate weight-related concerns. Open dialogue with healthcare providers about any side effects is crucial for adjusting dosages effectively. The collaboration between doctor and patient becomes essential in molding a personalized treatment plan that maximizes therapeutic outcomes while minimizing drawbacks. It's this tailored approach that gives Vraylar the capacity to make a meaningful difference in the lives of those struggling with mood disorders.

Conclusion

Conclusion

As we peer through the landscape of antidepressant alternatives to Wellbutrin SR, it's clear that the field of mental health treatment is as rich in diversity as the human experiences it seeks to address. Each medication, whether it's Lexapro, Zoloft, or one of the many others we've discussed, brings its own unique approach to elevating mood, combating anxiety, and helping individuals reclaim their sense of well-being. These options underscore the importance of tailoring mental health treatment to meet personal needs and contexts. This is crucial, considering that the journey to finding the right medication might involve a fair amount of trial and adjustment, but ultimately leads to more personalized care.

Engaging with healthcare professionals is a must when navigating these choices. Their guidance can illuminate subtleties about each drug, helping you weigh the benefits and possible side effects. This collaborative approach ensures that the decision process is aligned with your mental health needs and lifestyle. Notably, medications like Lexapro and Zoloft are often introduced in conversations about transitioning from or augmenting with Wellbutrin SR, pointing to their established presence in mental health treatments. As such, education around these alternatives enriches the dialogue with your doctor, where you can tailor a regimen that feels right for you.

There are some fascinating insights from respected professionals about choosing the right antidepressants. For instance, Dr. Elaine Little remarks,

"The right match between patient and medication can often be found by exploring beyond the conventional choices, considering both pharmacological effects and lifestyle integration."
Such perspectives underscore the dynamic nature of mental health care and the importance of considering a multitude of factors in your journey toward stability and improvement.

While seeking potential alternatives, it may be insightful to consider data around effectiveness and usage. Here's an illustrative table outlining basic data about some of these alternatives:

MedicationMain UseTypical Dosage
LexaproDepression10-20mg daily
ZoloftDepression/Anxiety50-200mg daily
CymbaltaDepression, Pain30-60mg daily

We hope that the information presented here sheds light on what might be a suitable step forward. Whether you're looking to manage depression or other related conditions, these alternatives offer a breadth of options to discuss with your healthcare provider. Remember, finding the right medication can be as much about the journey as it is about the destination. Prioritize open communication with your doctor to navigate this path successfully.

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